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KMID : 0366919990110000291
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Sungkyun Pharmceutical Journal
1999 Volume.11 No. 0 p.291 ~ p.295
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SYSTEMICALLY ADMINISTERED CAPSAZEPINE PREVENTS THE CAPSAICIN-INDUCED FUNCTIONAL DESENSITIZATION AND LOSS OF SUBSTANCE P-LIKE IMMUNOREACTIVITY (SP-LI) IN GUINEA-PIG BRONCHI
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Jung, Yi-Sook
Cho, Tai-Soon/Moon, Chang-Hyun/Lee, Buyean/Lee, Sun-Mee/Shin, Hwa-Sup
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Abstract
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Abstract. In this study, we investigated whether the systemically administered capsazepine can prevent the capsaicin-induced desensitization ex vivo I guinea-pig bronchi. Pretreatment with capsaicin (2.5, 5 and 10 mg/kg, s.c.) induced the functional desensitization and the loss of substance P-like immunoreactivity (SP-LI) with a similar potency (ED_50: 3.31±0.57 and 4.81±0.89 mg/kg, respectively) in isolated guinea-pig bronchi. Capsazepine (30 mg/kg, s.c.) co-administered with capsaicin (5 mg/kg, s.c.) prevented the capsaicin (5 mg/kg, s.c.)-induced functional desensitization and loss of SP-LI. These results suggest that capsazepine can antagonize systemically the desensitizing action of capsaicin at the level of receptor, preventing the loss of SP-LI and the establishment of functional desensitization in guinea-pig bronchi. ⓒ 1999 Elsevier Science Inc.
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